HOTW (or decade): Surpreme

From Wiki- Given free rein over Supreme and the wider Maximum (later Awesome) universe, Moore created a storyline to both entirely reinvent the character's world, and meld it with Liefeld's extant continuity. In Moore's first issue, Supreme returns to Earth and discovers that he is living in a new revision of reality.

The new version of Supreme has a secret identity as Ethan Crane, a mild-mannered artist for Dazzle Comics whose powers are a result of a childhood exposure to a meteorite made of Supremium, an element which can alter reality. When not saving the world as a superhero, Crane illustrates the adventures of Omni-Man, a Supreme-like character being reintroduced with a change of writers.

Echoing this change, Supreme encounters a number of previous/retired and parallel iterations of himself living in another reality, called the "Supremacy." The Supremacy is a form of afterlife for characters whose stories had ended or have been written out of current continuity. After experiencing amnesia, Supreme's returning memories are told on the page in flashback form revising and ret-conning the character's complex and oft-rewritten backstory, often in pastiche style evoking different periods of comics history.

Darius Dax, a Lex Luthor-like evil genius and Supreme's antagonist, is introduced in this storyline. Dax dies twice in the series, the first time in prison from lymphatic cancer caused by exposure to Supremium.  Back to me:

I never had much desire to "read" Image comic books, since they were mostly drawings in a style I didn't care for.  However, Mr. Owari himself got me hooked on this when Alan Moore took over, and it is truly great.  Supreme is everything Superman should be, and Moore kept the family, and even Radar, the dog.  It is great.